Neuroprotective role of Tinospora cordifolia extract in streptozotocin induced neuropathic pain

Diabetic Neuropathy (DN) is one of the prevailing micro vascular complications diabetes which can be characterized by neuropathic pain. Streptozotocin (STZ) induced in rat has been increasingly used as a model painful diabetic neuropathy. STZ injection leads to neurotoxicity peripheral nerves that development Peripheral model. The present study was aimed at exploring protective role Tinospora cordifolia extract and evaluating mechanisms responsible for attenuating Neuropathic pain markers like hyperalgesia, allodynia motor deficits were assessed before after treatment with 250 mg/kg 500 dose cordifolia. Oxidative stress markers, NGF expression sciatic nerve observed seven weeks treatment. Our results demonstrated leaf significantly relieved thermal hyperalgesia increasing antioxidant enzyme levels, decreasing lipid peroxidation Nerve growth factor (NGF) nerves. findings highlighted beneficial effects oral administration pain, possibly through strong activity inducing m RNA